This complete mouse duodenoscope system uses an ultra-thin, flexible, articulating probe sized for the narrow anatomy of mice and designed to enter the duodenum for visual observation. An integrated portable display supports real-time HD imaging and one-touch photo and video capture. A separate air and water module supports irrigation and insufflation during a procedure to reveal fine tissue lesions. The system is designed for animal experiments and pharmacological and pathological research, with straightforward and stable operation for a range of small-animal endoscopy research needs.